SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITIES OF N-ARYL SUBSTITUTED BENZENESULPHONAMIDE DERIVATIVES Page No: 5117-5123

Eze Florence Uchenna , Onyeyilim Ebuka Leonard ,Ugwu David Izuchukwu , Ezeokonkwo Mercy Amarachi, Udaya Priscilia Obioma , Uzoewulu Chiamaka Peace, Eze Cosmas Chiweike, Okonkwo Ifeoma Vivian

Keywords: Sulphonamides, anti-inflamatory, spectroscopy, aromatic amines and benzenesulphonyl chlorides.

Abstract: The synthesis of these novel N-aryl substituted benzenesulphonamid derivatives was reported using benzenesulphonyl chloride in a mixture of acetone and pyridine as a solvent and base respectively. This was achieved by coupling reaction of benzenesulphonyl chloride with different substituted aromatic amines. Their solubilities in different solvents and antiinflammatory activity of the products were also reported. The synthesized sulphonamide derivatives were characterized using FTIR, 1HNMR, 13CNMR and UV Spectroscopy. These sulphonamide derivatives reported in this work had been tested and confirmed to have anti-inflammatory activity in comparison with paracetamol as a standard drug.



[View Complete Article]