Ruchi Agarwal, VK Katiyar and Prabhakar Pradhan
Keywords: Drug delivery, stent, FEM, carotid artery, mass release.
Abstract: The release of substances in living tissues for therapeutic purposes is becoming quite important in medicine. Therefore the development of appropriate pharmacokinetic models for the numerical simulation of these release processes is important to increase the understanding. One of the main problems of the release processes from stents arises due to the different geometric changes caused by stenting in carotid arteries. To describe the drug release of stents to the wall of artery, a model is presented in this paper using appropriate transient flux boundary condition at the interface of arterial wall and fluid dynamical approach for the blood flow and arterial wall. This numerical simulation can provide a convenient way to study the effects of geometrical changes on the drug release of stents. The results are explained with appropriate plots presented at the end of the paper in order to illustrate the applicability of the present model under study.
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