Muhammad Waqas Iqbal, Saeed Akhter and Muhammad Athar Khawaja
Keywords: Hypocitraturia, calcium-oxalate stone, metabolic risk factors.
Abstract: Recurrence of stone disease is a well known clinical problem. This study was undertaken to identify the urinary metabolic abnormalities associated with idiopathic calcium-oxalate stone formation. Urinary metabolic abnormalities were determined in 53 adult idiopathic calcium oxalate stone formers based on 24hour urine collection on a free choice diet. Forty-two (79.2%) were male and 11 (20.7%) were female. Mean age was 39.5years with range from 18-77 years. Recurrent stone formers were 60.3% and 33.9% had multiple stones. Hypocitraturia was the most common abnormality found in 81.2% stone formers. Low urine volume was found in 26.4% of patients; 11.7% had hyperoxaluria followed by hypercalciuria in 11.5% and hyperuricosuria in 1.9% patients. Hypocitraturia and low urinary volume were the predominant urinary metabolic abnormalities in idiopathic calcium-oxalate stone formers.
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