EA. Al Omireeni, NJ Siddiqi and AS Alhomida
Keywords: Sodium fluoride; hydroxyproline; collagen; magnesium chloride.
Abstract: Magnesium chloride (MgCl2) has been reported to protect against sodium fluoride (NaF) induced toxicity. This study was undertaken to study the effect of MgCl2 on NaF induced alteration in rat kidney hydroxyproline fractions and collagen. Four groups of rats were studied (each consisting of 4-6 rats) (i) normal rats: (ii) rats injected with MgCl2: (iii) rats injected with NaF: (iv) rats injected with MgCl2 followed by NaF. Results show that MgCl2 and NaF treatment alone and together caused a significant (p < 0.05) decrease in kidney protein, free, peptide–bound, protein-bound, total hydroxyproline and soluble collagen hydroxyproline. Administration of MgCl2 before NaF did not restore the altered parameters to normal levels. However administration of MgCl2 before NaF restored insoluble collagen hydroxyproline which was altered by NaF to near normal levels. Though MgCl2 has been reported to be protective against the toxic effect of NaF, it has no significant effect on NaF induced changes in kidney hydroxyproline/collagen except insoluble collagen Hyp.
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