Canadian Journal of Pure & Applied Sciences

Abstract: Most of patients with acromegaly suffer from DM2. Excess GH production in active acromegaly indicate that inhibits osteoclasts throughout RANK-RANKL axis. Our aim is to determine the differences in the levels of RANKL in male patients with diabetic acromegaly and compare with male DM 2 patients and some related parameters, and if their level can possible use to follow up the patients with active acromegaly. Forty eight were enrolled in this study, (28) patients with DM2, (28) acromegaly patients with DM 2 and (28) healthy subject as a control group. Serum of RANKL, GH and insulin resistance were measured in all groups. RANKL level were showed significant decreased differences in patients with diabetes acromegaly compared with control group, non significant decreased differences in patients with DM2 when compared with control group and a significant negative correlation between RANKL and GH and IR. We conclude that serum RANKL levels were decrease in active acromegaly and its correlate with GH, so that possible RANKL can be used to follow up the male patients with active acromegaly and we suggest that it can be used therapeutically for better management of patients with active acromegaly.