Rajbir Bhatti, S Kaur, J Singh and MPS Ishar
Keywords: Cinnamomum zeylanicum, diabetic neuropathy, hyperalgesia
Abstract: Diabetic neuropathy is generally considered to be one of the most common complications of diabetes. Neuropathic pain is the most troublesome and early symptom of diabetic neuropathy, and has been recognized as one of the most difficult types of pain to treat due to its multifactorial pathogenesis. The aim of the present study was to evaluate the antinociceptive effect of volatile oil from Cinnamomum zeylanicum on hyperalgesia due to alloxan induced diabetes in rats. Diabetes was induced with single intra peritoneal injection of alloxan monohydrate (150mg/kg b.w.). Animals were divided into different groups. Treatment groups received cinnamon oil from 3rd day onward upto 14th day at different doses (5, 10 and 20mg/kg b.w.; i.p.). Diabetic control animals received normal saline (0.9% NaCl; 1ml/kg). After 2 weeks, rats were tested in tail immersion and hot plate assays. Diabetic control rats exhibited significant hyperalgesia along with increased plasma glucose levels as compared with normal rats. Cinnamon oil treatment significantly decreased thermal hyperalgesia and the plasma glucose levels as compared with diabetic control rats. These results indicate the protective effect of volatile oil from the bark of Cinnamomum zeylanicum on hyperalgesia due to alloxan induced diabetes in rats.
[View Complete Article]