Fatma Hashem, Hemaia Motawea, Manal Shabana, Mai Khalil and Taha Al-Alfy
Keywords: Ehretia wallichiana, phenolics, anticancer activity
Abstract: Globally researchers are agreed that diet is the single greatest contributor to human cancer, and maybe associated with 35-70% of the incidence of the disease. Although various carcinogens are present in foods, their effects are minor compared with dietary components that inhibit the cancer process. The crude extract (80% ethanol extract) of leaves of Ehretia wallichiana Hook. f. & Thomson ex Gamble family Borginaceae was examined for their cytotoxic activity against different cell lines. It showed higher activity against breast cancer (IC50=10 ?g/mL). Petroleum ether, chloroform and ethyl acetate extracts (successive to each other), showed high activity against breast cell line. Four phenolic compounds were isolated from Ehretia wallichiana. Two of them are flavonoids: quercetin 3-O-?-(6\\\'\\\'-galloyl glucopyranoside) and quercetin-3-O-?-glucopyranoside. The third is a precursor of coumarin 5-hydroxy-6- methoxybenzofuran-3-carbaldehyde and the fourth is p- methoxybenzoic acid (p-anisic acid). They were identified by their spectroscopic data.
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