Joga Singh, Sudhir Sharma, Paramdeep Singh, Gurjeet Singh, Ravinder Dang and Neena Bedi
Keywords: Intranasal, per-oral, antidepressant, forced swim test, venlafaxine
Abstract: Intranasal administration is a non-invasive method of drug delivery which may bypass the BBB to allow therapeutic substances direct access to the central nervous system. Recently direct delivery of drugs from nasal cavity to the CNS via the olfactory pathway is attracting increasing attention in order target the drugs directly to the CNS for the treatment of diseases like Schizophrenia, Meningitis, Parkinson’s disease, Alzheimer’s disease as well as depression also. This alternative approach can also lead to reduction in systemic side effects. The study investigated the plasma pharmacokinetics and brain uptake of DOV 21947 (Triple Reuptake Inhibitor) and venlafaxine a serotoninnorepinephrine reuptake inhibitor in Swiss albino mice after oral and intranasal administration. Enhanced pharmacological effect was observed which was evaluated by means of forced swimming test, suggesting that intranasal administration of drug produced higher direct delivery to CNS as well as to systemic circulation. Thus, offering a promising route of administration and an alternative to per-oral administration.
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