Balbir Singh, Tilak Raj, MPS Ishar, S Sateesh Kumar, RK Jaggi and Anupam Sharma
Keywords: Ocimum sanctum, O. basilicum, anti-malarial activity, Plasmodium berghei.
Abstract: Different extractives from leaves and roots of Ocimum sanctum Linn. and O. basilicum Linn. have been evaluated for in vivo anti-malarial activity using Peter’s 4-day suppressive test against Plasmodium berghei in mice. Ethanol extracts of roots of both plants exhibited maximum anti-malarial activity amongst various extracts viz., petroleum ether, chloroform, ethanol and water at the dose of 800 mg/kg in mice. The results were observed on the 4th and 7th day. Ethanolic extract of O. sanctum roots showed maximum antiplasmodial activity of 3.2 ± 0.74 at dose of 800mg/kg on day 4th. However, O. basilicum root extract showed maximum activity of 4.9 ± 0.96 at dose 800mg/kg on day 4th. Maximum activity of ethanoic extract was observed on day 4th.
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