MACFADYENA UNGUIS-CATI (L.) A. GENTRY, A SOURCE OF FREE RADICAL SCAVENGER COUMESTROL Page No: 9-13

Fatma Abd EL-Megeed Hashem, Elsayed Ali Aboutabl, Maysa El-Sayed Moharam and Amal Abd El-Rasheed Maamoon

Keywords: Macfadyena unguis-cati, bignoniaceae, antioxidant activity, antibacterial activity

Abstract: Testing the successive extracts and coumarin- containing fraction isolated from Macfadyena unguis-cati for antioxidant activity by inhibiting the stable DPPH free radical, it showed high activity (93.9% inhibition) when compared with vitamin C (95.4% inhibition). Also successive extracts and 80% total ethanol extract showed moderate antimicrobial activity by inhibiting the growth of Bacillus cereus (grampositive bacteria) and E-coli (gram-negative bacteria). Fractionation of coumarin containing-fraction led to isolation of two compounds, the first is the coumestrol, 7-hydroxy, 4`, 5` dimethoxy coumestan and the second is 6-methoxy-2-(4`-methoxy-2`-hydroxyphenyl)-benzofuran- 3-carbaldehyde.



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